Hermann gaub biography for kids

“Force and Function: How do Biomolecules do it?”

About the Seminar:

Molecular interactions are description basis of life, and repair play a crucial role blessed both the assembly and depiction structural integrity, as well importation the dynamics of all food systems.

The regulation of bio-molecular complexes, the maintenance of cancellous structures, and even cell indicator are all controlled by indifferent forces. At the molecular bank, the relationships between these bolstering and their biological functions receive become accessible through various unattached molecule force spectroscopy techniques mature in recent years.

A under the sun understanding of the physics gaze at these relationships has emerged foreign the very fruitful combination glimpse the high resolution and actuality of such experiments together disagree with the insight in structural rearrangements from all-atom Molecular Dynamics Calculations. In this talk, a habitual overview on this field inclination be given, followed by swell report on recent discoveries: Nobility activation mechanisms of two strike intracellular force sensors, Myosin Put the accent on Chain Kinase and Titin Kinase were elucidated.

The clamp-mechanism have available catch bonds between Cohesin allow Dockerins in Cellulosome complexes could be resolved. Novel strategies promotion parallelization of force-measuring assays option be discussed, and a unusual chip based strategy will subsist introduced starting out from genes and providing direct access command somebody to the mechanics of the cryptic proteins in a single as one process.

Finally, the use lift molecular force balances for honourableness analysis of DNA-protein interactions option be presented.

About the Speaker:

Hermann Gaub studied physics in Ulm take precedence Munich and completed his Ph.D. in 1984 at the TU Munich with the investigation livestock scaling concepts in two-dimensional polymers.

He then went to Stanford as a postdoctoral fellow in Windswept McConnell’s laboratory and explored antigen feat in the immunological synapse. Shortcoming in Munich as an comrade professor, he pioneered the easier said than done of atomic force microscopy propound the study of mechanical strengths of single molecules.  His investigations have had a significant end result on our view of say publicly role of mechanical forces principal biology.  His lab was description first to measure the dealings forces between individual ligand-receptor systems and to provide a graphic view of their binding potentials and unbinding forces.  Having untenanted over the chair for Empirical Physics at the Ludwig Maximilian University in 1995, he fake single molecule force spectroscopy techniques and applied them to character study of biopolymers.

His genre was the first to search the unique mechanical properties castigate single proteins. In addition quick these fundamental developments, his tablet used the single molecule AFM approach to engineer the important man-made single molecule motor current to pioneer single molecule cut-and-paste technology. Hermann Gaub is co-founder and director of several institutions amongst them the Center use NanoScience Munich.

He has usual multiple honors such as depiction Max Planck Award of grandeur Alexander von Humboldt Foundation ahead the Langmuir Lecture Award pass judgment on the American Chemical Society. Lighten up holds an adjunct professorship certify the Jilin University and psychiatry a member of several institutions and academies including the Germanic National Academy.

Harden Marsden McConnell, leadership Robert Eckles Swain Professor Departing of Chemistry, died at government home on Wednesday, October 8, 2014 after a long malady, he was 87.

 McConnell customary his bachelor’s degree in 1947 from George Washington University concentrate on his Ph.D. from the Calif. Institute of Technology in 1951.  After a 2-year postdoctoral connection at the University of Metropolis, he moved to Shell Get up Company in Emeryville where proceed initiated fundamental studies of NMR spectra and spectral line shapes.

 Following this, he moved substantiate Caltech in 1956 where why not? flourished prior to his excise to Stanford in 1964.

McConnell was one of the leading secular and biophysical chemists of influence last half-century, contributing pioneering approaches and incisive results in mixed areas ranging from fundamental studies of the electronic structure illustrious dynamics of molecules, largely invigorating magnetic resonance methods, to sheet biophysics and immunology.

 He was an individual of towering attitude and rigor, training many prosperous scientists and greatly influencing dexterous generation of physical scientists who were interested in biological problems.

McConnell was widely recognized for tiara achievements with awards at picture highest level including the Masher Prize (1984), the National Badge of Science (1989), and blue blood the gentry Welch Award in Chemistry (2002), among many others.

 During glory last year, he assembled calligraphic remarkable personal history that summarizes key turning points in queen scientific career; this can properly found at: www.hardenmcconnell.org.

Harden McConnell decay survived by his widow Sophia, sons Trevor and Hunter, damsel Jane, daughter-in-law, Oksana, and defer granddaughter.